The n.e. has it's problems as well...long winters is a major one for most. Also, the area is a bottle neck for most of the pollutants caused form the rest of the country, especially from the midwest and southeast. It all heads up that way. There are more respiratory problems, more acidic water. Also, rember that black flies and mosquitos are nuisance during most of the summer especially if fishing inland from the coast. But, the N.E. has it quaint towns and lots of water within short drives.
The midwest...well it's the midwest.
The southwest is hot in the summer. I hope you enjoy shopping in air conditioned malls because that's about all can do in the summer. There's less water and it's farther apart from one stream/lake to the next. It's mostly treeless and I like trees. The people, well most of them are from somewhere else anyway.
The northwest may be the best. It's sort of a combination of all the other regions yet still has it's own flavor. The region's landscape with it's mountains, coastline, high desert, green valleys, is more diverse than any other area. The are numerous lakes and streams, sometimes within minutes of each other and some hours apart. There are big waters and not so big waters. In the winter there is rain in the valley's and if you like snow it's in the mountains waiting for you to enjoy. Summers and fall, well they are the best in the country, period! The people are both "regular" and eccentric. Many from elsewhere yet enough locals to keep it real. There are big cities/towns with lots of shopping and good eats. The fishing is as diverse as the topography with trout, bass, walleye, steelhead, etc. and of course salmon. Fishing is year round. Some high winter waters but still fishable most of the time. You can learn to use a spey rod for something new. I believe there are more bamboo rod makers in the region than anywhere else. There are more than several commercial rod and reel makers in the area as well. There are fly fishing/fly tying shows throughout year. N.Cali with it's numerous streams is close by and your not far from Idaho/MT if you really feel the need to go. The small towns are conservative and the cities are liberal. Oregon has no sales tax and Wash has no income tax. So, you pick or live in Wash and shop in Ore.

Fond memories of the firetrap 3 floor
apartment too. Downtown Sara was a mess back then and needed money to redo all the lovely victorian houses. Went back years later during my honeymoon and it
was cleaned up much. Still after growing up in WNY and the Buffalo winters, I'd never retire to anyplace that hit -40 in the winter.